↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Giedraitis Vilmantas) ;pers:(Ingelsson Erik);conttype:(scientificother)"

Search: WFRF:(Giedraitis Vilmantas) > Ingelsson Erik > Other academic/artistic

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Dumanski, Jan P., et al. (author) Smoking is associated with mosaic loss of chromosome Y 2015 In: Cancer Research. - 0008-5472 .- 1538-7445. ; 75 Journal article (other academic/artistic)
2.	Nowak, Christoph, et al. (author) Metabolite profiles during an oral glucose tolerance test reveal new associations with clamp-measured insulin sensitivity Other publication (other academic/artistic)abstract Impaired insulin sensitivity (IS) is a major risk factor for cardiovascular disease and type 2 diabetes. Metabolomic profiling during an oral glucose tolerance test (OGTT) can reveal early pathogenic alterations in healthy individuals. Our aim was to identify IS biomarkers and gain new pathophysiologic insights by applying untargeted metabolomics to repeated OGTT plasma samples in association with a hyperinsulinemic-euglycemic clamp assessment. We studied 192 metabolites identified by non-targeted liquid chromatography/mass spectrometry in plasma samples taken at 0, 30, and 120 min during an OGTT in 470 non-diabetic 71-yr-old men. Insulin sensitivity was associated with 35 metabolites at one or more time points in multivariable-adjusted linear regression. The trajectories of nine metabolites during the OGTT were related to IS, six of which (oleic and palmitoleic acid, decanoyl- and dodecanoylcarnitine, deoxycholate-glycine and hexose) showed no associations with IS in the baseline fasting state. The strongest effects were detected for medium-chain acylcarnitines, which increased between 30-120 min in insulin-resistant individuals compared to those with normal IS. In this large community sample, we identified novel associations between clamp-measured IS and metabolite profiles that became apparent only after an oral glucose challenge. Associations of differential medium-chain acylcarnitine and monounsaturated fatty acid trajectories with IS provide new insights into the pathogenesis of insulin resistance.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (1); other publication (1)

Type of content: other academic/artistic (2)Undo refine

Author/Editor: Lind, Lars (2); Ingelsson, Erik (2)Undo refine; Giedraitis, Vilmanta ... (2); Berne, Christian (1); Ingelsson, Martin (1); Lannfelt, Lars (1); show more...; Johannesson, Magnus (1); Nowak, Christoph (1); Fall, Tove (1); Ganna, Andrea (1); Magnusson, Patrik K ... (1); Pedersen, Nancy L (1); Shen, Xia (1); Janson, Eva Tiensuu (1); Dumanski, Jan P (1); Ärnlöv, Johan (1); Lönn, Mikael (1); Cesarini, David (1); Salihovic, Samira (1); Sundstrom, Johan (1); Lindgren, Cecilia M. (1); Morris, Andrew P. (1); Broeckling, Corey D. (1); Davies, Hanna (1); Rasi, Chiara (1); Forsberg, Lars A. (1); Prenni, Jessica (1); show less...

University: Uppsala University (1); University of Gävle (1); Södertörn University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2015 (1)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view